Self-poisoning ofMycobacterium tuberculosisby interrupting siderophore recycling
نویسندگان
چکیده
منابع مشابه
Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.
Siderophores are small iron-binding molecules secreted by bacteria to scavenge iron. Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis, produces the siderophores mycobactin and carboxymycobactin. Complexes of the mycobacterial membrane proteins MmpS4 and MmpS5 with the transporters MmpL4 and MmpL5 are required for siderophore export and virulence in Mtb. Here we show that, s...
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The siderophore pyoverdine (PVD) is a primary virulence factor of the human pathogenic bacterium Pseudomonas aeruginosa, acting as both an iron carrier and a virulence-related signal molecule. By exploring a number of P. aeruginosa candidate systems for PVD secretion, we identified a tripartite ATP-binding cassette efflux transporter, here named PvdRT-OpmQ, which translocates PVD from the perip...
متن کاملManagement of self poisoning.
Around 15%20% of the workload of medical units and 10% of the workload of accident and emergency departments in the United Kingdom are due to self poisoning.1 2 Episodes of self poisoning in the United Kingdom continue to rise, particularly in young men, and alcohol is often taken with the overdose.2 In general the severity of poisoning has diminished over the past 10 years with the introductio...
متن کاملAttitudes towards self-poisoning.
Self-poisoning now constitutes one of the prime emergencies in hospital medical practice. This paper describes the results of the study of the attitudes of physicians and senior nurses towards several common illnesses in the medical wards. The junior doctors and the nurses who frequently have primary responsibility for the care of the self-poisoners tend to show unfavourable attitudes towards t...
متن کاملPatterns of self poisoning.
A population of 935 hospital admissions for self poisoning over a five-year period, 1967-71, was taken from three general hospitals in the Chichester area. All admissions were followed up by use of coroner's records. The peak age group for accidental self poisonings was 0-9 with a further peak in the over 60 age group. The peak age for attempted suicides was 20-29. There were more women than me...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1311402111